CA2410023A1 - Coated nanoparticles - Google Patents
Coated nanoparticles Download PDFInfo
- Publication number
- CA2410023A1 CA2410023A1 CA002410023A CA2410023A CA2410023A1 CA 2410023 A1 CA2410023 A1 CA 2410023A1 CA 002410023 A CA002410023 A CA 002410023A CA 2410023 A CA2410023 A CA 2410023A CA 2410023 A1 CA2410023 A1 CA 2410023A1
- Authority
- CA
- Canada
- Prior art keywords
- nanoparticles
- group
- functional group
- coated
- microemulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/183—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1875—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle coated or functionalised with an antibody
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
- B01J13/18—In situ polymerisation with all reactants being present in the same phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0001—Post-treatment of organic pigments or dyes
- C09B67/0004—Coated particulate pigments or dyes
- C09B67/0005—Coated particulate pigments or dyes the pigments being nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/552—Glass or silica
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
- H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
- H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
- Y10T428/2995—Silane, siloxane or silicone coating
Abstract
The invention relates to a plurality of nanoparticles having a mean size of between 2 nm and 100 nm, each of said nanoparticles comprising a core comprising a metal; and a silica shell enveloping the core. The metal is selected from the group consisting of Ag and Cd.
Claims (31)
1. A plurality of nanoparticles having a mean size of less than 1 micron, each of said nanoparticles comprising a core and a silica shell enveloping the core.
2. The plurality of nanoparticles of claim 1, wherein the mean size is between nm and 300 nm.
3. The plurality of nanoparticles of claim 1, wherein the mean size is between nm and 10 nm.
4. The plurality of nanoparticles of claim 1, wherein the core is magnetic.
5. The plurality of nanoparticles of claim 4, wherein the core comprises a metal selected from the group consisting of magnetite, maghemite, and greigite.
6. The plurality of nanoparticles of claim 1, wherein the core comprises a pigment.
7. The plurality of nanoparticles of claim 6, wherein the pigment is an inorganic salt selected from, potassium permanganate, potassium dichromate, nickel sulfate, cobalt-chloride, iron(III) chloride, and copper nitrate.
8. The plurality of nanoparticles of claim 1, wherein the core comprises a dye selected from the group consisting of Ru/Bpy and Eu/Bpy.
9. The plurality of nanoparticles of claim 1, wherein the core comprises a metal selected from the group consisting of Ag and Cd.
10. The plurality of nanoparticles of claim 1, wherein the silica shell is derivatized with a functional group.
11. The plurality of nanoparticles of claim 10, wherein the functional group is a protein.
12. The plurality of nanoparticles of claim 11, wherein the functional group is an antibody.
13. The plurality of nanoparticles of claim 12, wherein the core comprises a metal selected from the group consisting of magnetite, maghemite, and greigite.
14. The plurality of nanoparticles of claim 10, wherein the functional group is a nucleic acid.
15. The plurality of nanoparticles of claim 10, wherein the functional group is a substance selected from the group consisting of biotin and streptavidin.
16. A method of making coated nanoparticles comprising the steps of:
providing a microemulsion;
providing a first aqueous solution of a first reactant and a second aqueous solution of a second reactant, the first reactant and second reactant being selected such that a solid precipitate forms upon mixing the first and second reactants together in an aqueous environment;
adding the first aqueous solution to a first aliquot of the microemulsion and the second aqueous solution to a second aliquot of the microemulsion;
mixing together the first and second aliquots to form a reaction mixture that reacts to form nanoparticle cores; and adding a coating agent to the cores to form coated nanoparticles.
providing a microemulsion;
providing a first aqueous solution of a first reactant and a second aqueous solution of a second reactant, the first reactant and second reactant being selected such that a solid precipitate forms upon mixing the first and second reactants together in an aqueous environment;
adding the first aqueous solution to a first aliquot of the microemulsion and the second aqueous solution to a second aliquot of the microemulsion;
mixing together the first and second aliquots to form a reaction mixture that reacts to form nanoparticle cores; and adding a coating agent to the cores to form coated nanoparticles.
17. The method of claim 16 wherein the microemulsion is a water-in-oil microemulsion.
18. The method of claim 17, wherein the water-in-oil microemulsion comprises water; a relatively polar liquid selected from the group consisting of isooctane, n-hexane, and cyclohexane; and a surfactant selected from the group consisting of AOT, TX-100, and CTAB.
19. The method of claim 18, wherein the water-in-oil microemulsion further comprises a cosurfactant.
20. The method of claim 19, wherein the cosurfactant is n-hexanol.
21. The method of claim 16, wherein the coated nanoparticles are coated with a silica shell.
22. The method of claim 21, wherein the coating agent comprises a reactive silicate selected from the group consisting of TEOS and APTS.
23. The method of claim 21, wherein the silica shell is derivatized with a functional group.
24. The method of claim 21, wherein the functional group is a protein.
25. The composition of claim 24, wherein the functional group is an antibody.
26. The composition of claim 24, wherein the nanoparticle cores comprise a metal selected from the group consisting of magnetite, maghemite, and greigite.
27. The composition of claim 21, wherein the functional group is a nucleic acid.
28. The composition of claim 21, wherein the functional group is a substance (selected from the group consisting of biotin and streptavidin.
29. A method of identifying cells expressing a preselected molecule comprising the steps of:
providing a plurality of cells at least some of which express the preselected molecule;
providing a plurality of silica-coated nanoparticles coated with a functional group that binds to the preselected molecule;
mixing the plurality of silica-coated nanoparticles with the plurality of cells to form a mixture;
placing the mixture under conditions that allow the nanoparticles to bind to cells expressing the preselected molecule; and analyzing the cells for bound nanoparticles.
providing a plurality of cells at least some of which express the preselected molecule;
providing a plurality of silica-coated nanoparticles coated with a functional group that binds to the preselected molecule;
mixing the plurality of silica-coated nanoparticles with the plurality of cells to form a mixture;
placing the mixture under conditions that allow the nanoparticles to bind to cells expressing the preselected molecule; and analyzing the cells for bound nanoparticles.
30. The method of claim 29, wherein the functional group is an antibody that specifically binds to the preselected molecule.
31. The method of claim 29, wherein silica-coated nanoparticles are fluorescent.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/572,469 | 2000-05-17 | ||
US09/572,469 US6548264B1 (en) | 2000-05-17 | 2000-05-17 | Coated nanoparticles |
PCT/US2001/040729 WO2001088540A1 (en) | 2000-05-17 | 2001-05-14 | Coated nanoparticles |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2410023A1 true CA2410023A1 (en) | 2001-11-22 |
CA2410023C CA2410023C (en) | 2010-03-16 |
Family
ID=24287937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2410023A Expired - Fee Related CA2410023C (en) | 2000-05-17 | 2001-05-14 | Coated nanoparticles |
Country Status (9)
Country | Link |
---|---|
US (3) | US6548264B1 (en) |
EP (2) | EP1287359B1 (en) |
JP (1) | JP2003533363A (en) |
AT (1) | ATE374946T1 (en) |
AU (2) | AU2001261841B2 (en) |
CA (1) | CA2410023C (en) |
DE (1) | DE60130757T2 (en) |
NZ (1) | NZ523078A (en) |
WO (1) | WO2001088540A1 (en) |
Families Citing this family (349)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050034330A1 (en) * | 1996-11-12 | 2005-02-17 | Baychar | Running shoes, hiking shoes and boots, snowboard boots, alpine boots, hiking boots, and the like, having waterproof/breathable moisture transfer characteristics |
US20040200094A1 (en) * | 1996-11-12 | 2004-10-14 | Baychar | Softboots and waterproof /breathable moisture transfer composite and liner for in-line skates, ice-skates, hockey skates, snowboard boots, alpine boots, hiking boots and the like |
AU1694301A (en) * | 1999-09-14 | 2001-04-17 | Biomedical Apherese Systeme Gmbh | Magnetic nanoparticles having biochemical activity, method for the production thereof and their use |
DE10013670A1 (en) * | 2000-03-20 | 2001-09-27 | Inst Neue Mat Gemein Gmbh | Process for separating at least one component from liquid or gaseous media comprises contacting the medium with a nano composite so that the components to be separated are partially bound with the nano composite |
US6773823B2 (en) * | 2000-04-07 | 2004-08-10 | University Of New Orleans Research And Technology Foundation, Inc. | Sequential synthesis of core-shell nanoparticles using reverse micelles |
US6548264B1 (en) * | 2000-05-17 | 2003-04-15 | University Of Florida | Coated nanoparticles |
ATE425457T1 (en) * | 2000-10-06 | 2009-03-15 | Life Technologies Corp | CELLS WITH A SPECTRAL SIGNATURE AND METHOD FOR THEIR PRODUCTION AND USE |
US20050059031A1 (en) * | 2000-10-06 | 2005-03-17 | Quantum Dot Corporation | Method for enhancing transport of semiconductor nanocrystals across biological membranes |
US20040067502A1 (en) * | 2000-10-11 | 2004-04-08 | Rolf Guenther | Multiplex assays using nanoparticles |
JP4463473B2 (en) | 2000-12-15 | 2010-05-19 | ジ・アリゾナ・ボード・オブ・リージェンツ | Metal patterning method using precursor-containing nanoparticles |
US7553662B2 (en) * | 2000-12-22 | 2009-06-30 | Keele University | Culturing tissue using magnetically generated mechanical stresses |
US7811768B2 (en) * | 2001-01-26 | 2010-10-12 | Aviva Biosciences Corporation | Microdevice containing photorecognizable coding patterns and methods of using and producing the same |
US7015047B2 (en) * | 2001-01-26 | 2006-03-21 | Aviva Biosciences Corporation | Microdevices having a preferential axis of magnetization and uses thereof |
WO2003049936A1 (en) * | 2001-04-13 | 2003-06-19 | Cornell Research Foundation, Inc. | Superparamagnetic nanostructured materials |
US6936181B2 (en) | 2001-10-11 | 2005-08-30 | Kovio, Inc. | Methods for patterning using liquid embossing |
ATE536993T1 (en) * | 2002-01-02 | 2011-12-15 | Visen Medical Inc | AMINE FUNCTIONALIZED SUPERPARAMAGNETIZED NANOPARTICLES FOR THE SYNTHESIS OF BIOCONJUGATES |
DE10201084A1 (en) * | 2002-01-14 | 2003-07-24 | Bayer Ag | Magnetic particles containing silicon, process for their production and use of the particles |
JP2005517625A (en) * | 2002-02-15 | 2005-06-16 | ナノフェイズ テクノロジーズ コーポレイション | Composite nanoparticle material and method for producing the same |
IL148350A0 (en) * | 2002-02-25 | 2002-09-12 | J G Systems Inc | Processing and repairing emulsions and microemulsions for use in optical fibers |
DE60320780D1 (en) * | 2002-04-22 | 2008-06-19 | Univ Florida | FUNCTIONALIZED NANOPARTICLES AND USE METHOD |
US7217512B2 (en) * | 2002-05-09 | 2007-05-15 | Corning Incorporated | Reagent and method for attaching target molecules to a surface |
US7670623B2 (en) * | 2002-05-31 | 2010-03-02 | Materials Modification, Inc. | Hemostatic composition |
GB0214209D0 (en) | 2002-06-19 | 2002-07-31 | Univ Keele | Method |
US20080131648A1 (en) * | 2003-06-23 | 2008-06-05 | Solid Water Holdings | Waterproof/breathable, moisture transfer, soft shell alpine boots and snowboard boots, insert liners and footbeds |
EP1376129B1 (en) * | 2002-06-27 | 2007-10-10 | Toyo Boseki Kabushiki Kaisha | Magnetic carrier for biological substance, production method thereof and isolation method of biological substance using the same |
GB0215185D0 (en) | 2002-07-01 | 2002-08-07 | Genovision As | Binding a target substance |
US6957608B1 (en) | 2002-08-02 | 2005-10-25 | Kovio, Inc. | Contact print methods |
US6878184B1 (en) | 2002-08-09 | 2005-04-12 | Kovio, Inc. | Nanoparticle synthesis and the formation of inks therefrom |
US7176036B2 (en) * | 2002-09-20 | 2007-02-13 | Arrowhead Center, Inc. | Electroactive microspheres and methods |
US20040076961A1 (en) * | 2002-10-21 | 2004-04-22 | Lewis Mark A. | Biomolecule retaining material and methods for attaching biomolecules to a surface |
US7195908B2 (en) * | 2002-10-31 | 2007-03-27 | Corning Incorporated | Supports treated with triamine for immobilizing biomolecules |
US7560160B2 (en) * | 2002-11-25 | 2009-07-14 | Materials Modification, Inc. | Multifunctional particulate material, fluid, and composition |
US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
ES2208121B1 (en) * | 2002-11-29 | 2005-08-16 | Consejo Sup. Investig. Cientificas | ANTIBODIES AND IMMOBILIZED ANTIGENS ON SILICON MAGNETIC PARTICLES AS BIOSENSORS. |
EP1631259A4 (en) | 2002-12-18 | 2006-08-02 | Hough Ear Inst | Otologic nanotechnology |
US7666410B2 (en) | 2002-12-20 | 2010-02-23 | Kimberly-Clark Worldwide, Inc. | Delivery system for functional compounds |
US6888862B2 (en) * | 2002-12-20 | 2005-05-03 | Eastman Kodak Company | Dye-doped polymer nanoparticle gain medium |
US20040120373A1 (en) * | 2002-12-20 | 2004-06-24 | Eastman Kodak Company | Dye-doped polymer nanoparticle gain medium for use in a laser |
JP3993089B2 (en) * | 2002-12-26 | 2007-10-17 | 良幸 川添 | Multiple particles and method for producing the same |
US7078276B1 (en) | 2003-01-08 | 2006-07-18 | Kovio, Inc. | Nanoparticles and method for making the same |
US7147921B2 (en) * | 2003-04-04 | 2006-12-12 | Ppg Industries Ohio, Inc. | Anti-fouling coatings containing silica-coated copper |
US20040254419A1 (en) * | 2003-04-08 | 2004-12-16 | Xingwu Wang | Therapeutic assembly |
EP1617808A4 (en) * | 2003-04-25 | 2011-11-02 | Penn State Res Found | Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds |
WO2005016824A2 (en) * | 2003-05-05 | 2005-02-24 | The Research Foundation Of State University Of Newyork | Synthesis of nanoparticles by an emulsion-gas contacting process |
JP2007516426A (en) * | 2003-05-16 | 2007-06-21 | ユニバーシティー オブ ロチェスター | Colorimetric and fluorescent methods for the detection of oligonucleotides |
US20060166249A1 (en) * | 2003-05-16 | 2006-07-27 | University Of Rochester | Methods for separating short single-stranded nucleic acid from long single-and double-stranded nucleic acid, and associated biomolecular assays |
US20060239907A1 (en) * | 2003-06-03 | 2006-10-26 | The Trustees Of The University Of Pennsylvania | Stealthy nano agents |
US7723311B2 (en) * | 2003-06-18 | 2010-05-25 | Nanobiomagnetics, Inc. | Delivery of bioactive substances to target cells |
US8651113B2 (en) * | 2003-06-18 | 2014-02-18 | Swr&D Inc. | Magnetically responsive nanoparticle therapeutic constructs and methods of making and using |
US7344491B1 (en) * | 2003-11-26 | 2008-03-18 | Nanobiomagnetics, Inc. | Method and apparatus for improving hearing |
IL157437A0 (en) * | 2003-07-14 | 2004-03-28 | Superseal Ltd Superseal Ltd | Hydrophobic aggregate and applications thereof |
JP2007530397A (en) * | 2003-07-16 | 2007-11-01 | ザ ユニヴァーシティー オブ リーディング | Composite nanoparticles |
CN1312479C (en) * | 2003-08-08 | 2007-04-25 | 清华大学 | Nano fluorescent magnetic particle and its preparing method |
US20050112155A1 (en) * | 2003-08-11 | 2005-05-26 | Franck Giroud | Cosmetic composition comprising a passivated and optionally coated metal particles |
US20070026407A1 (en) * | 2003-09-08 | 2007-02-01 | Kazuko Matsumoto | Novel fine fluorescent particle |
WO2005034205A2 (en) * | 2003-10-06 | 2005-04-14 | Dow Corning Corporation | Self assembling nanoparticle-polymer hybrids |
US8092595B1 (en) * | 2003-10-10 | 2012-01-10 | Sandia Corporation | Self-assembly of water-soluble nanocrystals |
US7879350B2 (en) * | 2003-10-16 | 2011-02-01 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using colloidal nanoparticles |
US7794737B2 (en) * | 2003-10-16 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Odor absorbing extrudates |
US7754197B2 (en) | 2003-10-16 | 2010-07-13 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using coordinated polydentate compounds |
US7488520B2 (en) * | 2003-10-16 | 2009-02-10 | Kimberly-Clark Worldwide, Inc. | High surface area material blends for odor reduction, articles utilizing such blends and methods of using same |
US7413550B2 (en) | 2003-10-16 | 2008-08-19 | Kimberly-Clark Worldwide, Inc. | Visual indicating device for bad breath |
US7837663B2 (en) | 2003-10-16 | 2010-11-23 | Kimberly-Clark Worldwide, Inc. | Odor controlling article including a visual indicating device for monitoring odor absorption |
US7678367B2 (en) | 2003-10-16 | 2010-03-16 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using metal-modified particles |
US7438875B2 (en) | 2003-10-16 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using metal-modified silica particles |
TWI240094B (en) * | 2003-12-11 | 2005-09-21 | Univ Nat Cheng Kung | Gradient refractive-index plastic rod and method for making the same |
GB0329310D0 (en) * | 2003-12-18 | 2004-01-21 | Univ Keele | Method |
US20050282182A1 (en) * | 2003-12-30 | 2005-12-22 | Universal Bio Research Co., Ltd. | Reaction vessel and reaction apparatus comprising three-dimensional particle array |
WO2005071412A2 (en) * | 2004-01-09 | 2005-08-04 | Applera Corporation | Phosphor particle coded beads |
US7846201B2 (en) * | 2004-02-20 | 2010-12-07 | The Children's Hospital Of Philadelphia | Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex |
US8562505B2 (en) | 2004-02-20 | 2013-10-22 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
US9028829B2 (en) * | 2004-02-20 | 2015-05-12 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
US7190264B2 (en) * | 2004-03-05 | 2007-03-13 | Simon Fraser University | Wireless computer monitoring device with automatic arming and disarming |
JP2005265654A (en) * | 2004-03-19 | 2005-09-29 | Hitachi Maxell Ltd | Compounded particles |
US7745001B2 (en) * | 2004-03-23 | 2010-06-29 | University Of New Orleans Research And Technology Foundation, Inc. | Synthesis of nanoassemblies containing luminescent quantum dots and magnetic nanoparticles |
EP1730516A1 (en) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Method and device for evaluation of pharmaceutical compositions |
US20050220714A1 (en) * | 2004-04-01 | 2005-10-06 | Susan Kauzlarich | Agents for use in magnetic resonance and optical imaging |
US20060018835A1 (en) * | 2004-04-02 | 2006-01-26 | General Electric Company | Nanoparticles with inorganic core and methods of using them |
ATE547442T1 (en) * | 2004-04-02 | 2012-03-15 | Nexttec Gmbh | METHOD FOR PRODUCING A COMPOSITE SORPTION MATERIAL FOR THE CHROMATOGRAPHIC SEPARATION OF BIOPOLYMERS |
US20070281567A1 (en) * | 2004-04-05 | 2007-12-06 | Solid Water Holding | Waterproof/breathable technical apparel |
US20070141940A1 (en) * | 2005-10-28 | 2007-06-21 | Lightweight, breathable, waterproof, soft shell composite apparel and technical alpine apparel | |
US20070294920A1 (en) * | 2005-10-28 | 2007-12-27 | Soft shell boots and waterproof /breathable moisture transfer composites and liner for in-line skates, ice-skates, hockey skates, snowboard boots, alpine boots, hiking boots and the like | |
CN1232608C (en) * | 2004-04-06 | 2005-12-21 | 中国科学院长春应用化学研究所 | Method for synthesizing nano semiconductor luminescence material on interface bewteen liquid-liquid |
US7258786B2 (en) * | 2004-04-13 | 2007-08-21 | Eastman Kodak Company | Container for inhibiting microbial growth in liquid nutrients |
US7384545B2 (en) * | 2004-04-13 | 2008-06-10 | Eastman Kodak Company | Container for inhibiting microbial growth in liquid nutrients |
US7361275B2 (en) * | 2004-04-13 | 2008-04-22 | Eastman Kodak Company | Use of derivatized nanoparticles to minimize growth of micro-organisms in hot filled drinks |
US20050226911A1 (en) * | 2004-04-13 | 2005-10-13 | Bringley Joseph F | Article for inhibiting microbial growth in physiological fluids |
US7357863B2 (en) * | 2004-04-13 | 2008-04-15 | Eastman Kodak Company | Container for inhibiting microbial growth in liquid nutrients |
EP1743174B1 (en) * | 2004-04-20 | 2013-03-20 | Emory University | Multimodality nanostructures, methods of fabrication thereof, and methods of use thereof |
US7462452B2 (en) * | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
US7407816B2 (en) | 2004-05-07 | 2008-08-05 | Gentius, Inc | Isoelectric particles and uses thereof |
CA2569067C (en) * | 2004-06-01 | 2013-04-02 | James H. Adair | Unagglomerated core/shell nanocomposite particles |
DE502005008485D1 (en) * | 2004-06-04 | 2009-12-24 | Basf Se | METHOD FOR MARKING MATERIALS |
FI120318B (en) * | 2004-06-23 | 2009-09-15 | M Real Oyj | Silicon containing starch composites, process for making them and use in making paper and paperboard |
KR101076578B1 (en) | 2004-06-23 | 2011-10-24 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Methods and compositions for the detection of biological molecules using a two particle complex |
US20050287680A1 (en) * | 2004-06-25 | 2005-12-29 | Srivatsa Venkatasubbarao | Multianalyte assay method |
US7405002B2 (en) * | 2004-08-04 | 2008-07-29 | Agency For Science, Technology And Research | Coated water-soluble nanoparticles comprising semiconductor core and silica coating |
KR100604976B1 (en) | 2004-09-03 | 2006-07-28 | 학교법인연세대학교 | Water-Soluble Nanoparticles Stabilized with Multi-Functional Group Ligands |
US7534489B2 (en) * | 2004-09-24 | 2009-05-19 | Agency For Science, Technology And Research | Coated composites of magnetic material and quantum dots |
WO2006037837A1 (en) * | 2004-10-01 | 2006-04-13 | Turun Yliopisto | Dye particle and its preparation and use |
FR2877571B1 (en) * | 2004-11-05 | 2007-04-13 | Nanobiotix Sarl | NANOPARTICLES WITH INTRACELLULAR TARGETING ELEMENT, PREPARATION AND USES |
US8043480B2 (en) * | 2004-11-10 | 2011-10-25 | The Regents Of The University Of Michigan | Methods for forming biodegradable nanocomponents with controlled shapes and sizes via electrified jetting |
US7947772B2 (en) * | 2004-11-10 | 2011-05-24 | The Regents Of The University Of Michigan | Multiphasic nano-components comprising colorants |
JP4690418B2 (en) * | 2004-11-10 | 2011-06-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Multiphase nanoparticles |
US8187708B2 (en) * | 2004-11-10 | 2012-05-29 | The Regents Of The University Of Michigan | Microphasic micro-components and methods for controlling morphology via electrified jetting |
KR20070097439A (en) * | 2004-11-15 | 2007-10-04 | 오스트레일리언뉴클리어사이언스앤드테크놀로지오거나이제이션 | Solid particles from controlled destabilisation of microemulsions |
US20090098044A1 (en) * | 2004-11-15 | 2009-04-16 | Australian Nuclear Science And Technology Organisation | Solid particles from controlled destabilisation of microemulsions |
JP4916654B2 (en) * | 2004-11-16 | 2012-04-18 | 国立大学法人東北大学 | Method for producing nanocomposite structure |
US7306963B2 (en) * | 2004-11-30 | 2007-12-11 | Spire Corporation | Precision synthesis of quantum dot nanostructures for fluorescent and optoelectronic devices |
US7514725B2 (en) * | 2004-11-30 | 2009-04-07 | Spire Corporation | Nanophotovoltaic devices |
US7524776B2 (en) * | 2004-11-30 | 2009-04-28 | Spire Corporation | Surface-activation of semiconductor nanostructures for biological applications |
US20060147943A1 (en) * | 2004-12-30 | 2006-07-06 | Lewis Mark A | Substrates having pendant epoxide groups for binding biomolecules and methods of making and using thereof |
US20080135490A1 (en) * | 2005-01-07 | 2008-06-12 | Board Of Trustees Of The University Of Arkansas | Quantum dot biolabeling and immunomagnetic separation for detection of contaminants |
US7699979B2 (en) * | 2005-01-07 | 2010-04-20 | Board Of Trustees Of The University Of Arkansas | Separation system and efficient capture of contaminants using magnetic nanoparticles |
US20060217893A1 (en) * | 2005-01-07 | 2006-09-28 | Yanbin Li | Method for detecting an unknown contaminant concentration in a substance |
US8062729B2 (en) | 2005-01-14 | 2011-11-22 | Ndsu Research Foundation | Polymeric material with surface microdomains |
US20060293396A1 (en) * | 2005-01-14 | 2006-12-28 | Eastman Kodak Company | Amine polymer-modified nanoparticulate carriers |
EP2244270B1 (en) | 2005-01-20 | 2012-06-06 | Luminex Corporation | Microspheres having fluorescent and magnetic properties |
US8084275B2 (en) * | 2005-02-08 | 2011-12-27 | Fujifilm Corporation | Magnetic composite body, production method thereof, method for removing substance with mannose on its surface, and method for concentrating substance with mannose on its surface |
CA2598558C (en) | 2005-02-14 | 2013-04-02 | Australian Nuclear Science & Technology Organisation | Layered nanoparticles |
US7629179B2 (en) * | 2005-03-03 | 2009-12-08 | University Of North Dakota | Surfaces coated with target-induced fluorescent compounds for detection of target elements |
US7781228B2 (en) | 2005-04-07 | 2010-08-24 | Menon & Associates, Inc. | Magnetic resonance system and method to detect and confirm analytes |
US8084001B2 (en) * | 2005-05-02 | 2011-12-27 | Cornell Research Foundation, Inc. | Photoluminescent silica-based sensors and methods of use |
WO2006121920A2 (en) * | 2005-05-05 | 2006-11-16 | Beth Israel Deaconess Medical Center, Inc. | Micro-scale resonant devices and methods of use |
JP2008543602A (en) * | 2005-05-09 | 2008-12-04 | エヌディーエスユー リサーチ ファウンデーション | Antifouling substance containing polyamine-crosslinked polysiloxane |
EP1721603A1 (en) * | 2005-05-11 | 2006-11-15 | Albert-Ludwigs-Universität Freiburg | Nanoparticles for bioconjugation |
EP1726609A1 (en) * | 2005-05-25 | 2006-11-29 | DSM IP Assets B.V. | Hydrophobic coating |
CA2611606C (en) | 2005-06-17 | 2016-03-29 | Kim Suzanne Finnie | Particles comprising a releasable dopant therein |
US20100063263A1 (en) | 2005-06-23 | 2010-03-11 | Siemens Medical Solutions Diagnostics Gmbh | Magnetic particles with a closed ultrathin silica layer, method for the production thereof and their use |
JP2007040978A (en) * | 2005-06-30 | 2007-02-15 | Fujifilm Corp | Method for separating objective element using magnetic nanoparticles |
IL169678A (en) | 2005-07-14 | 2010-11-30 | Innova Sa | Sweetener compositions |
KR100731913B1 (en) | 2005-09-20 | 2007-06-25 | 한양대학교 산학협력단 | Method for manufacturing nanohybrid particle using for biomolecule detection, biomolecule detection system, biomolecule detection method, and analysis apparatus using for biomolecule detection using nanohybrid particle |
US20100259259A1 (en) * | 2005-09-21 | 2010-10-14 | Markus Zahn | Systems and methods for tuning properties of nanoparticles |
WO2007044711A1 (en) * | 2005-10-07 | 2007-04-19 | University Of Florida Research Foundation, Inc. | Multiple component nanoparticles for multiplexed signaling and optical encoding |
KR100771773B1 (en) * | 2005-11-01 | 2007-10-30 | 삼성전기주식회사 | A Composite Nickel Particle and A Preparing Method Thereof |
KR100745744B1 (en) * | 2005-11-11 | 2007-08-02 | 삼성전기주식회사 | A coating method of nano particle |
AU2006317439A1 (en) * | 2005-11-28 | 2007-05-31 | National Research Council Of Canada | Multifunctional nanostructure and method |
CN101356116B (en) * | 2005-12-06 | 2011-11-09 | Lg化学株式会社 | Core-shell type nanoparticles and method for preparing the same |
US7592042B1 (en) | 2005-12-19 | 2009-09-22 | Fujifilm Corporation | Reverse micelle method of producing core/shell particles |
EP1973575B1 (en) | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
US20080267557A1 (en) * | 2005-12-29 | 2008-10-30 | Zheng Wang | Integrated Magneto-Optical Devices for Uni-Directional Optical Resonator Systems |
JP5603013B2 (en) | 2006-01-12 | 2014-10-08 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | Nanoparticle composition and method for producing and using |
US10100266B2 (en) | 2006-01-12 | 2018-10-16 | The Board Of Trustees Of The University Of Arkansas | Dielectric nanolubricant compositions |
US20070166730A1 (en) | 2006-01-19 | 2007-07-19 | Menon & Associates, Inc. | Magnetic resonance system and method to detect and confirm analytes |
CA2571904A1 (en) * | 2006-02-15 | 2007-08-15 | Fio Corporation | System and method of detecting pathogens |
DE102006007564A1 (en) * | 2006-02-16 | 2007-08-30 | Röhm Gmbh | Nanoscale superparamagnetic poly (meth) acrylate polymers |
JP4711306B2 (en) * | 2006-02-20 | 2011-06-29 | 双葉電子工業株式会社 | Nanocarbon particle dispersion, method for producing the same, and method for producing core-shell type nanocarbon particles |
KR100745745B1 (en) * | 2006-02-21 | 2007-08-02 | 삼성전기주식회사 | Nano-composite material and the maunfacturing method for the same |
KR100713745B1 (en) * | 2006-02-27 | 2007-05-07 | 연세대학교 산학협력단 | Water-soluble magnetic or metal oxide nanoparticles coated with ligands and preparation method thereof |
JP2007269770A (en) * | 2006-03-09 | 2007-10-18 | Mitsubishi Chemicals Corp | Functional magnetic super-nanoparticle and use thereof |
WO2007112356A2 (en) * | 2006-03-24 | 2007-10-04 | University Of Florida Research Foundation, Inc. | Core-shell nanocapsules and applications thereof |
WO2007110917A1 (en) * | 2006-03-27 | 2007-10-04 | Tokyo Institute Of Technology | Process for producing polymer-coated ferromagnetic particle, and polymer-coated ferromagnetic particle |
JP4568862B2 (en) * | 2006-04-14 | 2010-10-27 | 独立行政法人産業技術総合研究所 | Core-shell type particle and method for producing the same |
WO2007123846A2 (en) * | 2006-04-17 | 2007-11-01 | Rensselaer Polytechnic Institute | Synthesis, functionalization and assembly of monodisperse high-coercivity silica-capped fept nanomagnets of tunable size, composition and thermal stability from microemulsions |
WO2007124131A2 (en) * | 2006-04-20 | 2007-11-01 | The University Of North Carolina At Chapel Hill | Hybrid nanomaterials as multimodal imaging contrast agents |
US7977103B2 (en) | 2006-04-20 | 2011-07-12 | Kimberly-Clark Worldwide, Inc. | Method for detecting the onset of ovulation |
WO2007146680A1 (en) * | 2006-06-06 | 2007-12-21 | Florida State University Research Foundation , Inc. | Stabilized silica colloid |
WO2007149310A2 (en) * | 2006-06-16 | 2007-12-27 | The Regents Of The University Of Michigan | Multiphasic biofunctional nano-components and methods for use thereof |
DE102006030690A1 (en) * | 2006-07-04 | 2008-01-10 | Grimm, Friedrich, Dipl.-Ing. | Synthetically producing silicic acid, useful e.g. as cosmetic product, drying agent, food additive and as insulating material, comprises doping silicic acid with a metal ion to give micro- and nano-scalic highly dispersed pigment |
US20080058473A1 (en) * | 2006-08-31 | 2008-03-06 | Yakov Freidzon | Latex for low VOC paint having improved block resistance, open time and water-softening resistance |
US20100120016A1 (en) * | 2006-09-01 | 2010-05-13 | Yanbin Li | Methods and systems for detection of contaminants |
US20080118687A1 (en) * | 2006-11-20 | 2008-05-22 | Alex Andrew Burns | Memory impregnated thermoplastic article |
US20100062073A1 (en) * | 2006-11-29 | 2010-03-11 | Ronald Arthur Beyerinck | Pharmaceutical compositions comprising nanoparticles comprising enteric polymers casein |
US8317002B2 (en) * | 2006-12-08 | 2012-11-27 | The Regents Of The University Of California | System of smart colloidal dampers with controllable damping curves using magnetic field and method of using the same |
CA2580589C (en) * | 2006-12-19 | 2016-08-09 | Fio Corporation | Microfluidic detection system |
FI20070174A0 (en) * | 2007-02-28 | 2007-02-28 | Delsitech Oy | A process for the preparation of silica compositions, silica compositions and their uses |
WO2008114532A1 (en) * | 2007-03-16 | 2008-09-25 | Konica Minolta Medical & Graphic, Inc. | Process for producing core/shell semiconductor nanoparticle and semiconductor nanoparticle aggregate produced thereby |
WO2008115854A2 (en) * | 2007-03-19 | 2008-09-25 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Multifunctional nanoparticles and compositions and methods of use thereof |
US8360321B2 (en) | 2007-04-02 | 2013-01-29 | Fio Corporation | System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology |
US20080255460A1 (en) * | 2007-04-13 | 2008-10-16 | Ethicon Endo-Surgery, Inc. | Nanoparticle tissue based identification and illumination |
US20100119612A1 (en) * | 2007-04-17 | 2010-05-13 | Bend Research, Inc | Nanoparticles comprising non-crystalline drug |
US20080269086A1 (en) * | 2007-04-30 | 2008-10-30 | Atanu Adhvaryu | Functionalized nanosphere lubricants |
US8703204B2 (en) * | 2007-05-03 | 2014-04-22 | Bend Research, Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer |
US20100080852A1 (en) * | 2007-05-03 | 2010-04-01 | Ronald Arthur Beyerinck | Phamaceutical composition comprising nanoparticles and casein |
US8309129B2 (en) * | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
US7811830B2 (en) * | 2007-05-18 | 2010-10-12 | New Mexico Technical Research Foundation | Photosensitizers for photodynamic therapy at infrared excitation |
WO2008149192A2 (en) * | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
US8287810B2 (en) | 2007-06-20 | 2012-10-16 | Board Of Trustees Of Michigan State University | Electrically-active ferromagnetic particle conductimetric biosensor test kit |
CN101821322B (en) | 2007-06-22 | 2012-12-05 | Fio公司 | Systems and methods for manufacturing quantum dot-doped polymer microbeads |
EP2174115B1 (en) * | 2007-07-09 | 2013-08-28 | Fio Corporation | Systems and methods for enhancing fluorescent detection of target molecules in a test sample |
WO2009010842A2 (en) * | 2007-07-13 | 2009-01-22 | Pfizer Products Inc. | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
US9023372B2 (en) * | 2007-07-18 | 2015-05-05 | University Of Maryland | Metal-enhanced fluorescence nanoparticles |
AP2684A (en) * | 2007-07-23 | 2013-06-12 | Fio Corp | data associated with biological and environmental test subjects A method and system for collating, storing, analyzing and enabling access to collected and analyzed |
US20090047222A1 (en) * | 2007-08-15 | 2009-02-19 | Ben Gu | Color Stable Peroxide Containing Dentifrice Formulations With Dye Encapsulated Silica Shell Nanoparticles |
WO2009026141A1 (en) * | 2007-08-17 | 2009-02-26 | University Of Florida Research Foundation, Inc. | Supercrystalline colloidal particles and method of production |
US20110028662A1 (en) * | 2007-08-31 | 2011-02-03 | Hybrid Silica Technologies, Inc. | Peg-coated core-shell silica nanoparticles and methods of manufacture and use |
US8709394B2 (en) * | 2007-09-28 | 2014-04-29 | Ndsu Research Foundation | Antimicrobial polysiloxane materials containing metal species |
EP2209549A4 (en) | 2007-10-12 | 2014-03-05 | Fio Corp | Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto |
WO2009061481A1 (en) | 2007-11-06 | 2009-05-14 | T2 Biosystems, Inc. | Small magnet and rf coil for magnetic resonance relaxometry |
WO2009069959A2 (en) * | 2007-11-30 | 2009-06-04 | Korea University Industrial & Academic Collaboration Foundation | A nanoparticle for separating peptide, method for preparing the same, and method for separating peptide using the same |
KR101077966B1 (en) | 2007-11-30 | 2011-10-31 | 고려대학교 산학협력단 | A nanoparticle for separating peptide, method for preparing the same, and method for separating peptide using the same |
US9233078B2 (en) * | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
US9724362B2 (en) * | 2007-12-06 | 2017-08-08 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
US8268436B2 (en) * | 2007-12-15 | 2012-09-18 | The Goodyear Tire & Rubber Company | Tire with indicia containing composite magnetic nanoparticles |
IL188647A0 (en) | 2008-01-08 | 2008-11-03 | Orina Gribova | Adaptable structured drug and supplements administration system (for oral and/or transdermal applications) |
US8357426B2 (en) * | 2008-01-11 | 2013-01-22 | Nanomateriales S.A. De C.V. | Single step milling and surface coating process for preparing stable nanodispersions |
KR101475520B1 (en) * | 2008-01-14 | 2014-12-23 | 삼성전자주식회사 | Quantum dot ink composition for inkjet printing and electronic device using the same |
WO2009102429A2 (en) * | 2008-02-11 | 2009-08-20 | University Of North Dakota | Method for producing nanoparticles of a selected size |
US7785998B2 (en) * | 2008-02-21 | 2010-08-31 | Micron Technology, Inc. | Methods of forming dispersions of nanoparticles, and methods of forming flash memory cells |
US20110135571A1 (en) * | 2008-02-22 | 2011-06-09 | Wenbin Lin | Hybrid nanoparticles as anti-cancer therapeutic agents and dual therapeutic/imaging contrast agents |
EP2265174B1 (en) | 2008-04-04 | 2018-06-06 | The Regents of The University of California | Functionalized magnetic nanoparticles and methods of use thereof |
US9011913B2 (en) * | 2008-04-04 | 2015-04-21 | The Regents Of The University Of California | Use of functionalized magnetic nanoparticles in cancer detection and treatment |
WO2009143720A1 (en) * | 2008-05-27 | 2009-12-03 | The Chinese University Of Hong Kong | Nanoparticles, methods of making same and cell labelling using same |
US20150147378A1 (en) * | 2008-05-30 | 2015-05-28 | Rutgers, The State University Of New Jersy | Copolymer-xerogel nanocomposites useful for drug delivery |
KR101421619B1 (en) * | 2008-05-30 | 2014-07-22 | 삼성전자 주식회사 | Nanocrystal-metal oxide-polymer composite and preparation method thereof |
US20120066926A1 (en) * | 2008-06-09 | 2012-03-22 | Kuniyil Prabhakaran | Non-toxic multifunctional nanoparticles using sonication-aided incorporation of dopants |
JP5279357B2 (en) * | 2008-06-12 | 2013-09-04 | キヤノン株式会社 | Composite particle, method for producing the same, dispersion, magnetic biosensing device, and magnetic biosensing method |
CA2729023C (en) | 2008-06-25 | 2013-02-26 | Fio Corporation | Bio-threat alert system |
US8465855B2 (en) * | 2008-07-16 | 2013-06-18 | International Business Machines Corporation | Protective coating of magnetic nanoparticles |
US20110105889A1 (en) * | 2008-07-17 | 2011-05-05 | Konica Minolta Medical & Graphic, Inc. | Nanoparticle labeling and system using nanoparticle labeling |
AP2011005589A0 (en) * | 2008-07-24 | 2011-02-28 | Tata Chemicals Ltd | A process for forming a rice husk ash composition. |
WO2010010569A1 (en) * | 2008-07-24 | 2010-01-28 | Tata Chemicals Ltd | A process for forming a rice husk ash composition |
US8216961B2 (en) * | 2008-08-27 | 2012-07-10 | Korea University Research And Business Foundation | Nanoparticles including metal oxide having catalytic activity |
US20100054988A1 (en) * | 2008-08-29 | 2010-03-04 | Kwangyeol Lee | Photocatalytic nanocapsule and fiber for water treatment |
CN105759021A (en) | 2008-08-29 | 2016-07-13 | Fio公司 | Single-use Handheld Diagnostic Test Device And Associated System And Method For Testing Biological And Environmental Test Samples |
US7897164B2 (en) * | 2008-10-30 | 2011-03-01 | Warsaw Orthopedic, Inc | Compositions and methods for nucleus pulposus regeneration |
US8221791B1 (en) | 2008-12-10 | 2012-07-17 | University Of Central Florida Research Foundation, Inc. | Silica-based antibacterial and antifungal nanoformulation |
US10080578B2 (en) | 2008-12-16 | 2018-09-25 | Nico Corporation | Tissue removal device with adjustable delivery sleeve for neurosurgical and spinal surgery applications |
EP2387721A4 (en) | 2009-01-13 | 2014-05-14 | Fio Corp | A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test |
US20100256524A1 (en) | 2009-03-02 | 2010-10-07 | Seventh Sense Biosystems, Inc. | Techniques and devices associated with blood sampling |
US20110171749A1 (en) * | 2009-03-02 | 2011-07-14 | Board Of Trustees Of Michigan State University | Nanoparticle tracer-based electrochemical dna sensor for detection of pathogens-amplification by a universal nano-tracer (aunt) |
US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
US9033898B2 (en) | 2010-06-23 | 2015-05-19 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
US8053744B2 (en) * | 2009-04-13 | 2011-11-08 | Src, Inc. | Location analysis using nucleic acid-labeled tags |
US8961825B2 (en) * | 2009-04-15 | 2015-02-24 | Cornell University | Fluorescent silica nanoparticles through silica densification |
EP2430112B1 (en) | 2009-04-23 | 2018-09-12 | The University of Chicago | Materials and methods for the preparation of nanocomposites |
US20100278749A1 (en) * | 2009-04-29 | 2010-11-04 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
US20100278734A1 (en) * | 2009-04-29 | 2010-11-04 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
US20100278748A1 (en) * | 2009-04-29 | 2010-11-04 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
US20100330366A1 (en) * | 2009-06-30 | 2010-12-30 | Keiser Bruce A | Silica-based particle composition |
SG10201403918RA (en) | 2009-07-09 | 2014-10-30 | Oshadi Drug Administration Ltd | Matrix carrier compositions, methods and uses |
US8727042B2 (en) | 2009-09-11 | 2014-05-20 | Baker Hughes Incorporated | Polycrystalline compacts having material disposed in interstitial spaces therein, and cutting elements including such compacts |
WO2011017649A2 (en) | 2009-08-07 | 2011-02-10 | Baker Hughes Incorporated | Polycrystalline compacts including in-situ nucleated grains earth-boring tools including such compacts, and methods of forming such compacts and tools |
US8800693B2 (en) | 2010-11-08 | 2014-08-12 | Baker Hughes Incorporated | Polycrystalline compacts including nanoparticulate inclusions, cutting elements and earth-boring tools including such compacts, and methods of forming same |
KR101123394B1 (en) | 2009-09-24 | 2012-03-23 | 한국세라믹기술원 | Manufacturing method of red ceramic pigment having thermal stability |
EP2488719B8 (en) * | 2009-10-15 | 2019-06-26 | Baker Hughes, a GE company, LLC | Polycrystalline compacts including nanoparticulate inclusions, cutting elements and earth-boring tools including such compacts, and methods of forming such compacts |
US9540822B2 (en) * | 2009-11-24 | 2017-01-10 | Certainteed Corporation | Composite nanoparticles for roofing granules, roofing shingles containing such granules, and process for producing same |
FR2954796B1 (en) * | 2009-12-24 | 2016-07-01 | Total Sa | USE OF NANOPARTICLES FOR THE MARKING OF PETROLEUM FIELD INJECTION WATER |
WO2011077838A1 (en) * | 2009-12-25 | 2011-06-30 | コニカミノルタエムジー株式会社 | Silica nanoparticles having fluorescent substance confined therein, and labeling agent for biosubstance |
US9005994B2 (en) * | 2010-01-14 | 2015-04-14 | University Of Central Florida Research Foundation, Inc. | Methods for biomolecule and biomolecule complex (BMC) detection and analysis and the use of such for research and medical diagnosis |
WO2011105736A2 (en) * | 2010-02-23 | 2011-09-01 | 서울대학교 산학협력단 | Surface-modified tantalum oxide nanoparticles, preparation method thereof, and contrast medium for x-ray computed tomography and highly dielectric thin film using same |
EP2542643A4 (en) * | 2010-03-01 | 2013-08-28 | Univ Florida | Near-ir indocyanine green doped multimodal silica nanoparticles and methods for making the same |
AU2011222514A1 (en) * | 2010-03-04 | 2012-09-20 | University Of Utah Research Foundation | Colloidal-crystal quantum dots as tracers in underground formations |
MX2012011104A (en) | 2010-03-30 | 2012-11-29 | Univ Central Florida Res Found | Multifunctional silica-based compositions and gels, methods of making them, and methods of using them. |
US8557329B2 (en) | 2010-05-06 | 2013-10-15 | International Business Machines Corporation | Method for silica encapsulation of magnetic particles |
WO2011156895A2 (en) * | 2010-06-14 | 2011-12-22 | National Research Council Of Canada | Magnetic nanoparticles and uses thereof |
US8703493B2 (en) | 2010-06-15 | 2014-04-22 | Src, Inc. | Location analysis using fire retardant-protected nucleic acid-labeled tags |
US9555136B2 (en) | 2010-06-21 | 2017-01-31 | University Of Washington Through Its Center For Commercialization | Coated magnetic nanoparticles |
DE102010030822A1 (en) * | 2010-07-01 | 2012-01-05 | Evonik Degussa Gmbh | Partially silylated magnetic particles and dispersions thereof |
ES2561824T3 (en) | 2010-07-16 | 2016-03-01 | Seventh Sense Biosystems, Inc. | Low pressure environment for fluid transfer devices |
US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
US8518288B2 (en) | 2010-07-27 | 2013-08-27 | Toyota Motor Engineering & Manufacturing North America, Inc. | Synthesis of nanocomposite thermoelectric material |
US8716027B2 (en) | 2010-08-03 | 2014-05-06 | Src, Inc. | Nucleic acid-labeled tags associated with odorant |
WO2012021801A2 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
DE102011010756A1 (en) | 2010-09-14 | 2012-03-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Photostimulable particle systems, processes for their preparation and uses |
IL208594A (en) | 2010-10-10 | 2014-11-30 | Innova Sa | Sweetener compositions comprising a solid eutectic melt mixture combination of cellulose and a sweetener carbohydrate and methods of producing same |
EP2628007B1 (en) * | 2010-10-13 | 2017-03-15 | Pharma Diagnostics NV | Method for coating nanoparticles |
US9482861B2 (en) | 2010-10-22 | 2016-11-01 | The Regents Of The University Of Michigan | Optical devices with switchable particles |
CN101966344B (en) * | 2010-10-29 | 2012-04-11 | 中国科学院上海硅酸盐研究所 | Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof |
US8992985B2 (en) | 2010-11-05 | 2015-03-31 | Massachusetts Institute Of Technology | Core-shell magnetic particles and related methods |
WO2012064802A1 (en) | 2010-11-09 | 2012-05-18 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
WO2012068178A1 (en) * | 2010-11-15 | 2012-05-24 | The Board Of Trustees Of The University Of Alabama For And On Behalf Of The University Of Alabama | Magnetic exchange coupled core-shell nanomagnets |
TWI403358B (en) * | 2010-12-29 | 2013-08-01 | Univ Nat Taiwan | Method for dispersing metallic nanoparticle and composite thereof |
US8802234B2 (en) * | 2011-01-03 | 2014-08-12 | Imra America, Inc. | Composite nanoparticles and methods for making the same |
WO2012097070A1 (en) * | 2011-01-11 | 2012-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | Mass dots: nanoparticle isotope tags |
JP5375855B2 (en) | 2011-02-22 | 2013-12-25 | トヨタ自動車株式会社 | Decorative coating |
EP2678444B1 (en) * | 2011-02-23 | 2016-02-17 | Eve Biomedical, Inc. | Rotation-dependent transcriptional sequencing systems and methods of using |
EP3345545B1 (en) | 2011-04-21 | 2021-10-20 | The Regents of The University of California | Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles |
EP2701598A1 (en) | 2011-04-29 | 2014-03-05 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
KR102237667B1 (en) | 2011-04-29 | 2021-04-12 | 세븐쓰 센스 바이오시스템즈, 인크. | Delivering and/or receiving fluids |
US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
EP2702406B1 (en) | 2011-04-29 | 2017-06-21 | Seventh Sense Biosystems, Inc. | Plasma or serum production and removal of fluids under reduced pressure |
WO2012173933A2 (en) | 2011-06-11 | 2012-12-20 | University Of Central Florida Research Foundation, Inc. | Activatable nanoprobes for intracellular drug delivery |
US9849512B2 (en) | 2011-07-01 | 2017-12-26 | Attostat, Inc. | Method and apparatus for production of uniformly sized nanoparticles |
EP3494974B1 (en) | 2011-07-08 | 2023-10-18 | The University of North Carolina at Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
WO2013020701A2 (en) | 2011-08-10 | 2013-02-14 | Magforce Ag | Agglomerating magnetic alkoxysilane-coated nanoparticles |
WO2013030240A1 (en) * | 2011-08-29 | 2013-03-07 | The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Phase transfer reactions |
US9491946B2 (en) | 2011-11-01 | 2016-11-15 | University Of Central Florida Research Foundation, Inc. | Ag loaded silica nanoparticle/nanogel formulation, methods of making, and methods of use |
US9734946B2 (en) | 2011-11-09 | 2017-08-15 | The Regents Of The University Of California | Superparamagnetic colloids with enhanced charge stability for high quality magnetically tunable photonic structures |
CN102406950A (en) * | 2011-11-29 | 2012-04-11 | 中国科学院上海硅酸盐研究所 | Manganese-based magnetic resonance imaging (MRI) contrast agent and preparation method and application thereof |
US20130243699A1 (en) * | 2011-12-07 | 2013-09-19 | Regents Of The University Of Minnesota | Biodegradable Magnetic Nanoparticles and Related Methods |
TWI525184B (en) | 2011-12-16 | 2016-03-11 | 拜歐菲樂Ip有限責任公司 | Cryogenic injection compositions, systems and methods for cryogenically modulating flow in a conduit |
KR20130084091A (en) | 2012-01-16 | 2013-07-24 | 삼성전자주식회사 | Image forming apparatus |
CN102580635B (en) * | 2012-01-19 | 2013-10-16 | 黑龙江大学 | Method for preparing double-property polymer microspheres |
WO2013131052A1 (en) | 2012-03-01 | 2013-09-06 | Quidel Corporation | Interactive test device and apparatus with timing mechanism |
US9207181B2 (en) | 2012-03-01 | 2015-12-08 | Quidel Corporation | System and apparatus for point-of-care diagnostics |
US8993921B2 (en) | 2012-06-22 | 2015-03-31 | Apple Inc. | Method of forming white appearing anodized films by laser beam treatment |
US8486870B1 (en) | 2012-07-02 | 2013-07-16 | Ajay P. Malshe | Textured surfaces to enhance nano-lubrication |
US8476206B1 (en) | 2012-07-02 | 2013-07-02 | Ajay P. Malshe | Nanoparticle macro-compositions |
DE102012211947A1 (en) | 2012-07-09 | 2014-01-09 | Evonik Industries Ag | Magnetic core-shell particles with high separation efficiency |
CA2879407A1 (en) * | 2012-07-18 | 2014-01-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of preparing silica-coated nanodiamonds |
US9493876B2 (en) * | 2012-09-14 | 2016-11-15 | Apple Inc. | Changing colors of materials |
US10557846B2 (en) * | 2012-11-16 | 2020-02-11 | Quantamatrix Inc. | Encoded polymeric microparticles |
CN103116026B (en) * | 2013-01-29 | 2015-04-15 | 南昌大学 | Quick detection method for food-borne pathogens based on immunomagnetic separation of Fe3O4 nano materials |
JP2016518240A (en) | 2013-02-15 | 2016-06-23 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | Particle functionalization |
US9296771B2 (en) | 2013-03-15 | 2016-03-29 | The United States Of America, As Represented By The Secretary Of The Navy | Large scale preparation method for functionalizing the surface of magnetic microparticles with an inorganic phosphorous dendrimer |
JP5714660B2 (en) * | 2013-07-11 | 2015-05-07 | トヨタ自動車株式会社 | Method for producing nanocomposite thermoelectric conversion material |
US9409148B2 (en) | 2013-08-08 | 2016-08-09 | Uchicago Argonne, Llc | Compositions and methods for direct capture of organic materials from process streams |
US9781936B2 (en) | 2013-10-09 | 2017-10-10 | University Of Central Florida Research Foundation, Inc. | Compositions, methods of making a composition, and methods of use |
US9181629B2 (en) | 2013-10-30 | 2015-11-10 | Apple Inc. | Methods for producing white appearing metal oxide films by positioning reflective particles prior to or during anodizing processes |
JP6590802B2 (en) | 2013-11-06 | 2019-10-16 | ザ ユニバーシティ オブ シカゴThe University Of Chicago | Nanoscale transporter for delivery or co-delivery of chemotherapeutic drugs, nucleic acids and photosensitizers |
US9839974B2 (en) | 2013-11-13 | 2017-12-12 | Apple Inc. | Forming white metal oxide films by oxide structure modification or subsurface cracking |
WO2015085189A1 (en) | 2013-12-06 | 2015-06-11 | Quidel Corporation | Method for reducing analyzer variability using a normalization target |
US9215877B2 (en) | 2014-02-05 | 2015-12-22 | University Of Central Florida Research Foundation, Inc. | Compositions including a vacancy-engineered(VE)-ZnO nanocomposite, methods of making a composition , method of using a composition |
EP2905034A1 (en) | 2014-02-06 | 2015-08-12 | Maillefer Instruments Holding S.À.R.L. | Irrigation solution with nanoparticles for endodontics |
US9446355B2 (en) | 2014-02-28 | 2016-09-20 | Pall Corporation | Porous polymeric membrane with high void volume |
US9764292B2 (en) | 2014-02-28 | 2017-09-19 | Pall Corporation | Porous polymeric membrane with high void volume |
US9737860B2 (en) | 2014-02-28 | 2017-08-22 | Pall Corporation | Hollow fiber membrane having hexagonal voids |
US9561473B2 (en) | 2014-02-28 | 2017-02-07 | Pall Corporation | Charged hollow fiber membrane having hexagonal voids |
US9302228B2 (en) | 2014-02-28 | 2016-04-05 | Pall Corporation | Charged porous polymeric membrane with high void volume |
US9776142B2 (en) | 2014-02-28 | 2017-10-03 | Pall Corporation | Porous polymeric membrane with high void volume |
US9309126B2 (en) | 2014-02-28 | 2016-04-12 | Pall Corporation | Rapidly dissolvable nanoparticles |
US9610548B2 (en) | 2014-02-28 | 2017-04-04 | Pall Corporation | Composite porous polymeric membrane with high void volume |
US20160242439A1 (en) | 2014-04-04 | 2016-08-25 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
US10231476B2 (en) | 2014-04-04 | 2019-03-19 | Douxmatok Ltd | Sweetener compositions and foods, beverages, and consumable products made thereof |
US10207004B2 (en) | 2014-04-04 | 2019-02-19 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
US9566552B2 (en) | 2014-04-07 | 2017-02-14 | Ford Global Technologies, Llc | Temperature maintenance and regulation of vehicle exhaust catalyst systems with phase change materials |
US9181838B2 (en) | 2014-04-07 | 2015-11-10 | Ford Global Technologies, Llc | Temperature maintenance and regulation of vehicle exhaust catalyst systems with phase change materials |
US20160010080A1 (en) * | 2014-07-09 | 2016-01-14 | Magqu Co., Ltd. | A method for preparing silica-coated magnetic bead |
GB201416354D0 (en) | 2014-09-16 | 2014-10-29 | Ecole Polytech | Monolayer nanocapsules |
US9885001B2 (en) | 2014-09-23 | 2018-02-06 | Attostat, Inc. | Fuel additive composition and related methods |
US9883670B2 (en) * | 2014-09-23 | 2018-02-06 | Attostat, Inc. | Compositions and methods for treating plant diseases |
US9919363B2 (en) | 2014-09-23 | 2018-03-20 | Attostat, Inc. | System and method for making non-spherical nanoparticles and nanoparticle compositions made thereby |
US10806694B2 (en) | 2014-10-14 | 2020-10-20 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
WO2016061256A1 (en) | 2014-10-14 | 2016-04-21 | The University Of Chicago | Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof |
US20160136307A1 (en) * | 2014-11-14 | 2016-05-19 | Massachusetts Institute Of Technology | Nanoparticles for magnetic particle imaging applications |
US20170326043A1 (en) * | 2014-12-19 | 2017-11-16 | Colgate-Palmolive Company | Stable Whitening Dentifrice Composition with Superior Aesthetics |
WO2016161348A1 (en) | 2015-04-01 | 2016-10-06 | Attostat, Inc. | Nanoparticle compositions and methods for treating or preventing tissue infections and diseases |
KR101781976B1 (en) * | 2015-04-08 | 2017-10-23 | 한국과학기술연구원 | Nano-structured hybrid particle, manufacturing method thereof, and device containing the particle |
US11473202B2 (en) | 2015-04-13 | 2022-10-18 | Attostat, Inc. | Anti-corrosion nanoparticle compositions |
EP3283580A4 (en) | 2015-04-13 | 2019-03-20 | Attostat, Inc. | Anti-corrosion nanoparticle compositions |
DE102015209594A1 (en) * | 2015-05-26 | 2016-12-01 | Siemens Aktiengesellschaft | Resistance covering for corona protection of an electrical machine |
US10201571B2 (en) | 2016-01-25 | 2019-02-12 | Attostat, Inc. | Nanoparticle compositions and methods for treating onychomychosis |
WO2017201528A1 (en) | 2016-05-20 | 2017-11-23 | The University Of Chicago | Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof |
IL254053B (en) * | 2016-08-19 | 2021-03-25 | Univ Nat Taiwan | Hollow silica nanoparticles with encapsulated bioactive ingredients, preparation process and applications thereof |
WO2018069388A1 (en) * | 2016-10-11 | 2018-04-19 | Khalifa University of Science and Technology | Coated chloride salt particles and methods of making and using the same |
JP7364552B2 (en) | 2017-08-02 | 2023-10-18 | ザ ユニバーシティ オブ シカゴ | Nanoscale metal-organic layers and metal-organic nanoplates for X-ray-induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
EP3704723B1 (en) * | 2017-10-31 | 2023-10-11 | F. Hoffmann-La Roche AG | Improved magnetic particles and uses thereof |
DE102017010263A1 (en) | 2017-11-07 | 2019-05-09 | Forschungszentrum Jülich GmbH | A method for producing hydrogenated amorphous silicon-containing composite colloids and for encapsulating substances with hydrogenated amorphous silicon-containing composite layers, and hydrogenated amorphous silicon-containing composite colloids and with silicon-containing composite layers encapsulated substances and their use |
US11018376B2 (en) | 2017-11-28 | 2021-05-25 | Attostat, Inc. | Nanoparticle compositions and methods for enhancing lead-acid batteries |
US11646453B2 (en) | 2017-11-28 | 2023-05-09 | Attostat, Inc. | Nanoparticle compositions and methods for enhancing lead-acid batteries |
CN107973301A (en) * | 2017-12-12 | 2018-05-01 | 河北科技大学 | One kind is based on T-shaped microreactor controllable preparation Nano-meter SiO_22Method |
US10702843B2 (en) | 2018-03-29 | 2020-07-07 | Baker Hughes, A Ge Company, Llc | Compositions of matter comprising suspended nanoparticles and related methods |
CA3041931A1 (en) * | 2018-05-02 | 2019-11-02 | Royal Melbourne Institute Of Technology | A multimodal pet/mri contrast agent and a process for the synthesis thereof |
US11747341B2 (en) | 2019-03-04 | 2023-09-05 | Waters Technologies Corporation | Methods of use for low-bind polypropylene plates and vials |
WO2022093793A1 (en) | 2020-10-27 | 2022-05-05 | Elucida Oncology, Inc. | Folate receptor targeted nanoparticle drug conjugates and uses thereof |
CN112774683B (en) * | 2020-12-31 | 2022-05-24 | 中国环境科学研究院 | Carbon-based coated Ac-Fe/Co catalyst, and microemulsion preparation method and application thereof |
WO2024014179A1 (en) * | 2022-07-11 | 2024-01-18 | キヤノン電子管デバイス株式会社 | Rotating anode x-ray tube |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4032471A (en) * | 1975-01-27 | 1977-06-28 | Eastman Kodak Company | Process for preparing yttrium oxide and rare earth metal oxide phosphors |
US4054465A (en) | 1976-09-29 | 1977-10-18 | Hercules Incorporated | Lead chromate pigments |
US4438156A (en) | 1982-09-30 | 1984-03-20 | International Business Machines Corporation | Mono-particle magnetic dispersion in organic polymers for magnetic recording |
US4661408A (en) * | 1986-03-18 | 1987-04-28 | E.I. Du Pont De Nemours And Company | Coated chromium dioxide particles |
FR2606419B1 (en) * | 1986-11-07 | 1994-04-01 | Commissariat A Energie Atomique | PROCESS FOR PRODUCING A FERROMAGNETIC COMPOSITION, FERROMAGNETIC LIQUID CRYSTAL OBTAINED BY THIS PROCESS AND DEVICE USING THE LIQUID CRYSTAL |
US5091206A (en) | 1987-10-26 | 1992-02-25 | Baxter Diagnostics Inc. | Process for producing magnetically responsive polymer particles and application thereof |
WO1993014022A1 (en) * | 1992-01-15 | 1993-07-22 | Battelle Memorial Institute | Process of forming metal compounds using reverse micelle or reverse microemulsion systems |
JPH0811691B2 (en) * | 1993-03-22 | 1996-02-07 | 工業技術院長 | Method for producing coprecipitated spherical fine particles containing yttrium / europium, coprecipitated sintered spherical fine particles and phosphor |
US6103379A (en) | 1994-10-06 | 2000-08-15 | Bar-Ilan University | Process for the preparation of microspheres and microspheres made thereby |
JPH08119631A (en) * | 1994-10-21 | 1996-05-14 | Shin Etsu Chem Co Ltd | Production of spherical oxide of rare earth element and its precursor |
US5695901A (en) | 1995-12-21 | 1997-12-09 | Colorado School Of Mines | Nano-size magnetic particles for reprographic processes and method of manufacturing the same |
US5637258A (en) * | 1996-03-18 | 1997-06-10 | Nanocrystals Technology L.P. | Method for producing rare earth activited metal oxide nanocrystals |
US5667716A (en) | 1996-07-01 | 1997-09-16 | Xerox Corporation | High magnetization aqueous ferrofluids and processes for preparation and use thereof |
US5874111A (en) | 1997-01-07 | 1999-02-23 | Maitra; Amarnath | Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles |
US6344272B1 (en) * | 1997-03-12 | 2002-02-05 | Wm. Marsh Rice University | Metal nanoshells |
WO1998051435A1 (en) * | 1997-05-14 | 1998-11-19 | Weixin Tang | Fully-coated, uniform-sized metallic particles |
US5879715A (en) | 1997-09-02 | 1999-03-09 | Ceramem Corporation | Process and system for production of inorganic nanoparticles |
US5958329A (en) | 1997-11-06 | 1999-09-28 | United States Enrichment Corporation | Method and apparatus for producing nanoparticles at a high rate |
US5990479A (en) * | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
EP0972563A1 (en) * | 1998-07-15 | 2000-01-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates |
US6036886A (en) * | 1998-07-29 | 2000-03-14 | Nanocrystals Technology L.P. | Microemulsion method for producing activated metal oxide nanocrystals |
US6251303B1 (en) * | 1998-09-18 | 2001-06-26 | Massachusetts Institute Of Technology | Water-soluble fluorescent nanocrystals |
US6306610B1 (en) * | 1998-09-18 | 2001-10-23 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
US6426513B1 (en) * | 1998-09-18 | 2002-07-30 | Massachusetts Institute Of Technology | Water-soluble thiol-capped nanocrystals |
US6326144B1 (en) * | 1998-09-18 | 2001-12-04 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
US6548264B1 (en) * | 2000-05-17 | 2003-04-15 | University Of Florida | Coated nanoparticles |
-
2000
- 2000-05-17 US US09/572,469 patent/US6548264B1/en not_active Expired - Fee Related
-
2001
- 2001-05-14 AU AU2001261841A patent/AU2001261841B2/en not_active Ceased
- 2001-05-14 JP JP2001584885A patent/JP2003533363A/en active Pending
- 2001-05-14 NZ NZ523078A patent/NZ523078A/en unknown
- 2001-05-14 CA CA2410023A patent/CA2410023C/en not_active Expired - Fee Related
- 2001-05-14 EP EP01935779A patent/EP1287359B1/en not_active Expired - Lifetime
- 2001-05-14 DE DE60130757T patent/DE60130757T2/en not_active Expired - Lifetime
- 2001-05-14 AT AT01935779T patent/ATE374946T1/en not_active IP Right Cessation
- 2001-05-14 EP EP07112218A patent/EP1867993A1/en not_active Withdrawn
- 2001-05-14 AU AU6184101A patent/AU6184101A/en active Pending
- 2001-05-14 WO PCT/US2001/040729 patent/WO2001088540A1/en active IP Right Grant
- 2001-11-13 US US10/010,807 patent/US6924116B2/en not_active Expired - Fee Related
-
2005
- 2005-07-25 US US11/188,459 patent/US7332351B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2001261841B2 (en) | 2004-04-01 |
DE60130757D1 (en) | 2007-11-15 |
US6548264B1 (en) | 2003-04-15 |
US6924116B2 (en) | 2005-08-02 |
DE60130757T2 (en) | 2008-07-17 |
US7332351B2 (en) | 2008-02-19 |
EP1867993A1 (en) | 2007-12-19 |
EP1287359B1 (en) | 2007-10-03 |
WO2001088540A1 (en) | 2001-11-22 |
EP1287359A1 (en) | 2003-03-05 |
CA2410023C (en) | 2010-03-16 |
NZ523078A (en) | 2004-09-24 |
JP2003533363A (en) | 2003-11-11 |
ATE374946T1 (en) | 2007-10-15 |
AU6184101A (en) | 2001-11-26 |
US20060228554A1 (en) | 2006-10-12 |
US20020098529A1 (en) | 2002-07-25 |
EP1287359A4 (en) | 2005-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2410023A1 (en) | Coated nanoparticles | |
US9512001B2 (en) | Fluorescent magnetic nanoparticles and process of preparation | |
AU2001261841A1 (en) | Coated nanoparticles | |
He et al. | Core/shell fluorescent magnetic silica-coated composite nanoparticles for bioconjugation | |
US7175912B2 (en) | Super-paramagnetic composite particle with core/shell structure, preparation method and use thereof | |
Teng et al. | Highly magnetizable superparamagnetic iron oxide nanoparticles embedded mesoporous silica spheres and their application for efficient recovery of DNA from agarose gel | |
JP2006097123A (en) | Metallic microparticle, manufacturing method therefor, and magnetic bead | |
Zhu et al. | Surfactant‐assisted synthesis and characterization of novel chain‐like CoNi alloy assemblies | |
Runowski et al. | Magnetic and luminescent hybrid nanomaterial based on Fe 3 O 4 nanocrystals and GdPO 4: Eu 3+ nanoneedles | |
JPWO2008035681A1 (en) | Coated fine metal particles and method for producing the same | |
WO2009119757A1 (en) | Coated fine metal particle and process for producing the same | |
Wang et al. | The synthesis of magnetic and fluorescent bi-functional silica composite nanoparticles via reverse microemulsion method | |
EP1335003A2 (en) | Magnetic carrier capable of binding with protein and purification method of protein utilizing the magnetic carrier | |
JP5419199B2 (en) | Magnetic inclusion particles, method for producing magnetic inclusion particles, immunoassay particles, and immunochromatography method | |
da Silva et al. | The role of magnetic nanomaterials in miniaturized sample preparation techniques | |
KR102188846B1 (en) | Manufacturing method of magnetic nanoparticles having yolk-shell structrure | |
Wang et al. | Synthesis of dual fluorescent encoding magnetic composite nanoparticles | |
CN105081342A (en) | Method to prepare hard-soft magnetic FeCo/SiO2/MnBi nanoparticles with magnetically induced morphology | |
CN107492433A (en) | A kind of iron-based soft magnetic composite of doping vario-property nickel powder and preparation method thereof | |
Chen et al. | Preparation of acicular/spl alpha/-Fe nanoparticles in a lamellar liquid crystalline phase | |
JP2005166967A (en) | Composite magnetic particle | |
Dumitrascu et al. | The use of derivatized magnetoliposomes for extraction of antibodies from aqueous solutions | |
Ping et al. | Preparation of magnetic iron/mesoporous silica composite spheres and their use in protein immobilization | |
EP3770927A1 (en) | Ferrofluid system containing gold particles | |
TWI446924B (en) | Manufacturing method of magnetic composite particles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |